CFA was notified at 6.02pm Saturday 17 September to reports of a bedroom fire at Celia Ct, Yarra Glen with one person was airlifted to The Alfred in serious condition with upper body injuries.
On arrival, crews found a single-storey dwelling involved.
The scene was declared under control at 6.33pm.
Eight CFA vehicles from Yarra Glen Fire Brigade, Coldstream CFA Fire Brigade, Yellingbo Rural Fire Brigade and Dixons Creek CFA and Bayswater CFA Fire Brigade were on scene, and police and ambulance also attended.
Fire investigators attended to try and determine a cause.